GAMES:I Have No Mouth, and I Must Scream
You must mount the root of your hdd, so the directory that Scream thinks it was installed to is the same as where DOSBox tells Scream it's being run from. It'll give you a "Can't open music resource file" error or similar, otherwise.
On setup, I installed it to the default C:\SCREAM\. For sound config:
MIDI music: Creative Labs Sound Blaster(TM) 16 Digital audio: Creative Labs Sound Blaster or 100% compatible
To play, I launched DOSBox and entered these commands:
Z:\>mount c c:\ Z:\>c: C:\>scream\s.exe
This is the only way I could get it working. So, it's not a DOSBox problem; the game was just coded funny, I guess.